For the 5-25 percent of MS patients who do not experience fatigue as a major symptom, is there a protective factor to be learned? Could we understand why they do not report having the most common symptom?

Fatigue is the most common symptom of MS and has had considerable impact on our quality of life. Personally, fatigue has impacted my life in more ways than one, as it tends to drive other symptoms such as depression. Studies say that fatigue occurs in 75-95 percent of MS patients. I am intrigued by the 5-25 percent of patients who do not experience fatigue. Are these patients newly diagnosed? Are there MS patients that are later in the disease that truly experience limited to no fatigue? If so, what could be protecting them from this common symptom, and can that help inform better treatment options for those who experience severe fatigue impacting QOL?